Preclinical Assessment of a SuFEx-Modified, CAIX-Targeted PET Probe [ <sup>68</sup> Ga]Ga–SF–DPI-4452 for Imaging Clear Cell Renal Cell Carcinoma
< 0.05). Biodistribution studies in mice and PET/CT imaging in cynomolgus monkeys further confirmed reduced gastrointestinal accumulation. Overall, SuFEx modification preserves tumor targeting while minimizing off-target uptake, supporting its potential for CAIX-targeted imaging and radionuclide therapy.
Authors
- 韩彦江
- Dan Shao (ORCID: https://orcid.org/0000-0002-5243-042X)
- Jiahao Xie
- Hubing Wu (ORCID: https://orcid.org/0000-0002-7546-5430)
- Wenlan Zhou (ORCID: https://orcid.org/0000-0001-9056-4835)
- Yijin Zou
- Y Q Huang
- You Cheng
- Ying Tian
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00678
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China