The relationship between homocysteine and post-stroke depression in patients with spontaneous intracerebral hemorrhage

INTRODUCTION: Depression after a stroke is the most frequent and burdensome neuropsychiatric post-stroke complication. This study aimed to determine the relationship between post-stroke depression (PSD) and the levels of homocysteine (HCY) in patients with spontaneous intracerebral hemorrhage (SICH). METHOD: (Hamilton Depression) scores and HCY levels at 3 m, the use of antidepressant medications and folic acid during the follow-up period in the group of patients diagnosed with PSD and hyperhomocysteinemia (HHcy) in the acute phase. RESULT: scores decreased significantly in the ADM plus folic acid group at the end of 3 m (P = 0.036). CONCLUSION: scores for the patients with comorbid PSD and HHcy.