Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression <i>in vitro</i> and <i>in vivo</i>

BACKGROUND: , a plant widely used in traditional Chinese medicine. METHODS: was evaluated in a mouse xenotransplantation model. RESULTS: Bruceine D significantly reduced the viability of NSCLC cells, promoted apoptosis, and inhibited the growth of tumors in a mouse xenograft model. Bruceine D was found to bind directly to STAT3, inhibiting glycolysis in NSCLC cells. Western blotting results suggested that the antitumor effects of bruceine D might be mediated by the inhibition of the phosphorylation and nuclear translocation of STAT3. CONCLUSION: . Bruceine D has potential application prospects in the field of anti-NSCLC therapy.