Copper-Catalyzed Asymmetric Propargylation of 5-Aminopyrazoles

-selective propargylation of 5-aminopyrazoles, and the target products were obtained in very high yields (up to 99%) and enantioselectivities (up to 97:3 er). Additionally, a scale-up reaction and postsynthetic modifications of the products have been presented.

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Publication Details

Journal
Organic Letters
Published
2026-05-08
DOI
https://doi.org/10.1021/acs.orglett.6c01240
Primary Topic
Catalytic Alkyne Reactions
Type
article
Field-Weighted Citation Impact
0.00

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article

Copper-Catalyzed Asymmetric Propargylation of 5-Aminopyrazoles

Ramprasad Begari, Aman Mourya, Vignesh Venkatachalam Pavalakodi, Alagiri Kaliyamoorthy
Organic Letters
Catalytic Alkyne Reactions
article

Copper-Catalyzed Asymmetric Propargylation of 5-Aminopyrazoles

Ramprasad Begari, Aman Mourya, Vignesh Venkatachalam Pavalakodi, Alagiri Kaliyamoorthy
article en

Abstract

-selective propargylation of 5-aminopyrazoles, and the target products were obtained in very high yields (up to 99%) and enantioselectivities (up to 97:3 er). Additionally, a scale-up reaction and postsynthetic modifications of the products have been presented.

Organic Letters
Indian Institute of Science Education and Research Thiruvananthapuram (IN)
Science and Engineering Research Board
Openalex Percentile: Top 9%
Catalytic Alkyne Reactions
DOISourceOpenAlex
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