Trends and patterns of antimicrobial resistance among Staphylococcus aureus isolated from various clinical specimens: a national laboratory-based AMR surveillance, 2020–2024
Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern responsible for a wide range of infections. In Ethiopia, patterns and trends of MRSA in various clinical specimens are limited. Therefore, this study aimed to determine the trend and pattern of S. aureus isolated from 16 AMR surveillance sentinel sites. Laboratory-based AMR surveillance data from 2020 to 2024 was collected from various clinical specimens. Culture and antimicrobial susceptibility testing were performed using standard microbiology techniques. The data were analyzed using WHONET 2025 software version 25.15.5 and SPSS version 22. A total of 4,243 S. aureus isolates were analyzed in 16 AMR sentinel sites; most of them were from health facilities in Addis Ababa (46.6%). The trend of penicillin resistance among tested isolates showed persistently high (~ 90%) between 2020 and 2024. The trend of MRSA showed a noticeable slight decline from 37% in 2021 and 2022 to 30% in the 2024 period, and its overall prevalence was 32.2% (95% CI 30.3, 34.2). There has been a slight declining trend of MRSA since 2022 and fluctuating resistance rates in routinely tested antimicrobials. The susceptibility of isolates to last-resort antibiotics remains promising for treatment. The significant presence of MRSA in participating hospitals warrants continuous surveillance and strengthens the implementation of infection prevention and control measures.
Authors
- Daniel Dejene Wondimagegnehu
- Etsehiwot Adamu Tsegaye
- Amete Mihret Teshale (ORCID: https://orcid.org/0000-0001-9028-6601)
- Negga Asamene Abera (ORCID: https://orcid.org/0000-0002-1299-1353)
- Dereje Mamuye Gebretsadik (ORCID: https://orcid.org/0000-0002-7472-5800)
- Gebrie Alebachew Belete
- Jemal Mohammed Hussien
- Zeleke Ayenew (ORCID: https://orcid.org/0000-0003-4216-6634)
- Addis Abebe
- Getachew Tollera Eticha
- Ebisa Fekede
- Surafel Fentaw Dinku (ORCID: https://orcid.org/0000-0002-8348-4965)
- Yesewbelay Minale Negesse
- Birhan Moges Ejigu
- Yonas Mekonnen Gebeyehu
- Dejenie Shiferaw Teklu (ORCID: https://orcid.org/0000-0002-6969-2768)
- Eshetu Gadisa (ORCID: https://orcid.org/0000-0001-6274-6412)
- Abebe Aseffa Negeri (ORCID: https://orcid.org/0000-0001-8113-6548)
- Senahara Korsa Wake
- Eyasu Tigabu Seyoum (ORCID: https://orcid.org/0000-0002-2362-9018)
- Tesfa Addis Kefale (ORCID: https://orcid.org/0009-0008-5269-4856)
- Dawit Sekata Duressa
- Gemechis Bulti Tura
- Estifanos Tsigie
- Bruke Gezhagene Birhanu
- Gemechu Tadese Leta
- Daniel Demissie Gebremariam
- Semira Ebrahim Geleto
- Mheret Tesfaye Gobena
- Tewodros Minwuyelet Anteneh
- Bethelhem Getu Bekele
- Degu Ashagrie Alemu
- Dawit Assefa Wendifraw
- Degefe Habte
- Mezgebu Nega Bizuneh
- Elias Seyoum Derebe
- Meseret Aseffa Oda
- Abera Abdeta Kitaba
- Degefu Beyene Gobena
- Rajiha Abubeker Ibrahim
Institutions
- Ethiopian Public Health Institute (ET)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41598-026-51962-5
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00