Photoredox-Catalyzed Radical–Polar Crossover Annulation To Access Silyl/Aryl/Alkyl-Substituted <i>N</i> -Aryl γ-Lactams
-aryl γ-lactams in good to excellent yields and diastereoselectivities under mild conditions. The potentiality of this method has been demonstrated in expedient synthesis of pharmaceutical drugs such as (±)-oxiracetam, (±)-phenotropil, (±)-phenibut.HCl, and (±)-pregabalin.
Authors
- Raghunath Chowdhury (ORCID: https://orcid.org/0000-0002-0395-7014)
- Pooja Goyal
- Akhil K. Dubey
Institutions
- Bhabha Atomic Research Centre (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acs.joc.6c00329
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Atomic Energy, Government of India
- Bhabha Atomic Research Centre