Triple Gene Variant Linked to Severe Hypertrophic Cardiomyopathy: A Case Report.

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, caused mainly by variations in sarcomere-related genes like MYH7, MYBPC3, and TTN. Its clinical presentation ranges from asymptomatic to sudden cardiac death, with severity influenced by the number and type of genetic variants. Most variants are single, but multiple variants can occur, increasing severity. A 38-year-old man with HCM, presenting with heart failure and a family history of sudden death, was found to have triple gene variants in TNNI3, TMEM43, and MYBPC3. This case is noteworthy for early onset, multiple variants, and family history.