Temperature‐Buffer Interplay Governs the Formation, Stability, and Degradation of POEGMA Nanogels

and the temperature of the biological medium. Nanogel degradation in citrate buffer and PBS was followed by dynamic light scattering and cryogenic transmission electron microscopy, and encapsulation and release of doxorubicin hydrochloride were demonstrated. Our findings highlight that translation from simplified aqueous solutions to biological media fundamentally alters nanogel formation, stability and degradation pathways. By identifying temperature-medium interdependencies as a key design parameter, this work provides chemically grounded guidelines for the rational development of nanogels made of thermoresponsive polymers intended for future applications.