Hydroxyapatite-Based 3D Tooth Models for Investigating Spatially Resolved Analysis of Biofilm Formation Dynamics
revealed significantly higher biofilm accumulation on the occlusal surfaces of the mandibular tooth models. In contrast, maxillary tooth models exhibited greater colonization on lateral surfaces. Restored tooth models showed increased biofilm formation on and around inlay and onlay materials. These morphologically accurate tooth models enable spatially resolved analysis of oral biofilms. This approach may enhance our understanding of microbial colonization and biofilm formation mechanisms.
Authors
- Geelsu Hwang (ORCID: https://orcid.org/0000-0001-7277-5639)
- H Kim
- Albert Kim (ORCID: https://orcid.org/0000-0003-1539-1246)
- Fahad T. Almutairi
- Kwidug Yun
- Sung-Hwan Choi (ORCID: https://orcid.org/0000-0002-1150-0268)
- Amanda Lee
- Markus B. Blatz
- Erica Adu
- Mahsa Jalali
- Rachel Park
- Ilchul Yoon
- Ryan Ong
- Pratik Nag
Institutions
- Yonsei University (KR)
- University of South Florida (US)
- California University of Pennsylvania (US)
- Chonnam National University Hospital (KR)
- General Department of Preventive Medicine (VN)
- International Craniofacial Institute (US)
- College Medical Center (US)
- Precision for Medicine (United States) (US)
- Yonsei University College of Dentistry
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-05-08
- DOI
- https://doi.org/10.1021/acsabm.5c02424
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Dental and Craniofacial Research
- Division of Materials Research