Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity
T cell infiltration, and suppresses tumor growth and metastatic burden. The system also prolongs survival and remains controllable by antibiotic-mediated clearance. These findings support a programmable microbial-cellular strategy for localized cytokine delivery and immune activation in immunologically cold tumors.
Authors
- Ruhua Liu
- Arabella Wan (ORCID: https://orcid.org/0009-0001-8310-2912)
- Chuwei Liu (ORCID: https://orcid.org/0000-0003-3473-8102)
- 张鹤腾
- Silke Neumann (ORCID: https://orcid.org/0000-0003-3818-8259)
- Huiya Cheng
- Qiusheng Zhou
- Qiaoping Wang
- Qijun Yao
- Jiarui Li
- Zitong Zhang
- Juan Fang
- Chengyuan Fu
- Jun Huang
- Yuan Deng
- Shijia Yan
- Min Xiao
- Zhi Wang
- Guohui Wan (ORCID: https://orcid.org/0000-0001-5170-7282)
- Heng Liang
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- National Medical Products Administration (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
- University of Otago (NZ)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.xcrm.2026.102801
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China