Moisture-Balanced Antibacterial Dressings Promote Wound Healing by Maintaining a Modulating Microenvironment

, respectively, and they were able to kill bacteria by destroying bacterial cell membranes. In a full-thickness infection mouse model, PU@[email protected] reduced the average healing time from 16-17 days (PU group or Vaseline group) to 12 days, accelerated re-epithelialisation, promoted granulation tissue formation and collagen deposition. Transcriptome sequencing showed that PU@[email protected] may regulate the Wnt pathway (which promotes regeneration) through up-regulation and NOD-like receptors and the RAS/PI3K/Akt/mTOR pathway (which causes inflammation) through down-regulation. Immunohistochemistry and ELISA validation showed that PU@[email protected] promoted the proliferation of proliferating cells (PCNA positive) and neovascularisation (CD31 positive) and reduced the expression levels of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α), which were consistent with the sequencing results. This study has verified that PU@[email protected] can regulate the humidity balance and antibacterial properties simultaneously, providing a dressing option for infected wounds repair.