The biological clock in parkinson’s disease: mechanisms and chronotherapy
Circadian disruption is increasingly recognized as a significant contributor to Parkinson's disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy's potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.
Authors
- Kun Yang
- Ying Liu
- Kangchao Sun
- Hong Liu
- Yuxiu Ma
- Yaru Wang
- Wenzhen Du
- Hao Ling
- Kai Wang
- Long Niu
Institutions
- Changzhi Medical College (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1038/s41531-026-01379-8
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00