COMPATIBILITY STUDIES OF AZITHROMYCIN AND PARACETAMOL COMBINATION FOR THE DEVELOPMENT AS SUPPOSITORIES NOVEL DRUG DELIVERY SYSTEMS

The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Azithromycin Dihydrate and Paracetamol drugs in formulated suppositories Drug Delivery Systems. Azithromycin is classified as a biopharmaceutics classification system (BCS) Class-IV. Preformulation, formulation and evaluation of Azithromycin to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve bioavailability and one of the most antibacterials agents. In the present study that the compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, preformulation parameters. Results showed that physical mixtures of antibacterials and analgesic, antipyretic and various excipients as PEG4000, Witepsol were evaluated for preformulation studies parameters. It was concluded that the drug Azithromycin Dihydrate and Paracetamol was found to be compatible which were selected for the formulation development of the Azithromycin and Paracetamol drugs in formulated suppositories Novel Drug Delivery Systems. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the NDDS (Novel Drug Delivery Systems) product development process.