Women's Knees Are Not Gender‐Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence

= 29.4, p < 0.001). Sex-disaggregated analyses were reported in 38% of mixed-sex studies, with profound neglect of psychosocial, preventive, and mechanistic outcomes. Intersectional analyses combining age, socioeconomic status, and context were extremely rare. Weighted gap scores highlighted very high deficiencies in SES, education, occupation, and LMIC representation, with minimal improvement over 24 years. KOA's evidence base does not merely underrepresent women; it systematically fails to generate clinically validated knowledge for them. As a result, interventions are routinely applied without clear evidence of the effectiveness across the population most affected, without mandatory sex-aggregated, mechanistic, and context-specific research.

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Publication Details

Journal
International Journal of Rheumatic Diseases
Published
2026-05-01
DOI
https://doi.org/10.1111/1756-185x.70657
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
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article

Women's Knees Are Not Gender‐Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence

Emmanuel Okon Enang, Ezra Onyedikachi Madu, Minha Awan
International Journal of Rheumatic Diseases
Osteoarthritis Treatment and Mechanisms
article

Women's Knees Are Not Gender‐Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence

Emmanuel Okon Enang, Ezra Onyedikachi Madu, Minha Awan
article en

Abstract

= 29.4, p < 0.001). Sex-disaggregated analyses were reported in 38% of mixed-sex studies, with profound neglect of psychosocial, preventive, and mechanistic outcomes. Intersectional analyses combining age, socioeconomic status, and context were extremely rare. Weighted gap scores highlighted very high deficiencies in SES, education, occupation, and LMIC representation, with minimal improvement over 24 years. KOA's evidence base does not merely underrepresent women; it systematically fails to generate clinically validated knowledge for them. As a result, interventions are routinely applied without clear evidence of the effectiveness across the population most affected, without mandatory sex-aggregated, mechanistic, and context-specific research.

International Journal of Rheumatic DiseasesVol. 29(5)
Enugu State University of Science and Technology (NG), Bahawal Victoria Hospital (PK), University of Calabar (NG)
Gender equality, Quality Education
Openalex Percentile: Top 5%
Osteoarthritis Treatment and Mechanisms
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Women's Knees Are Not Gender‐Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence — Emmanuel Okon Enang, Ezra Onyedikachi Madu, et al. · International Journal of Rheumatic Diseases (2026) | TGRS Research Map | TGRS