When tumor contact reshapes CAR-T cells
Repeated tumor contact leaves more behind than simple CAR-T exhaustion. This study by Gu et al. (https://doi.org/10.1084/jem.20252564) shows that chronic antigen exposure impairs a Rab5-dependent endocytic program, allowing trogocytosed antigen to accumulate, functional CAR to decline, and fratricide to increase.
Authors
- Sangwoo Park (ORCID: https://orcid.org/0000-0002-2701-3114)
- Marcela V. Maus (ORCID: https://orcid.org/0000-0002-7578-0393)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1084/jem.20260645
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00