Whole-genome doubling drives immune evasion by silencing antigen presentation
T cell infiltration. Our results underscore metabolic and epigenetic alterations as critical drivers of WGD-associated immune escape.
Authors
- Steffi Oesterreich (ORCID: https://orcid.org/0000-0002-2537-6923)
- Daniel D. Brown (ORCID: https://orcid.org/0000-0001-8682-6791)
- Laura E. Stevens (ORCID: https://orcid.org/0000-0002-6692-4009)
- Kornélia Polyák (ORCID: https://orcid.org/0000-0002-5964-0382)
- Anthony Letai (ORCID: https://orcid.org/0000-0002-1993-9013)
- Pilar Baldominos (ORCID: https://orcid.org/0000-0002-4988-6290)
- Pierre Foidart (ORCID: https://orcid.org/0000-0003-4198-271X)
- Yijia Jiang (ORCID: https://orcid.org/0000-0002-0239-6999)
- Adrian V. Lee (ORCID: https://orcid.org/0000-0001-9917-514X)
- Marco Seehawer (ORCID: https://orcid.org/0000-0003-0440-6967)
- Marie-Anne Goyette (ORCID: https://orcid.org/0000-0003-3199-2252)
- Lise Mangiante (ORCID: https://orcid.org/0000-0001-8309-0950)
- Yingtian Xie (ORCID: https://orcid.org/0000-0003-0206-457X)
- Jun Nishida (ORCID: https://orcid.org/0000-0001-5098-9361)
- Isaac S. Harris (ORCID: https://orcid.org/0000-0002-6855-2763)
- Xiao-Yun Huang (ORCID: https://orcid.org/0009-0007-8697-922X)
- Kathleen E. Houlahan (ORCID: https://orcid.org/0000-0002-2273-2099)
- Amatullah Tawawalla
- Brent T. Schlegel
- TashJae Scales
- Ernesto Rojas-Jimenez
- Salma Parvin
- Pengze Yan
- Cristina Irene Sotomayor Vivas
- Mahmoud Aarabi
- Henry W. Long
- Triet M. Bui
- Xintao Qiu
- Judith Agudo
- Paloma Cejas
- Rahul Kumar (ORCID: https://orcid.org/0009-0001-3552-6403)
- Zheqi Li
- Benedetto Diciaccio
- Christina Curtis
- Rong Li
- Xinran Cai
Institutions
- University of Pittsburgh (US)
- University of Rochester Medical Center (US)
- Magee-Womens Research Institute (US)
- Precision Therapeutics (United States) (US)
- Magee-Womens Hospital (US)
- Precision for Medicine (United States) (US)
- Dana-Farber Cancer Institute (US)
- UPMC Hillman Cancer Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Cell
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.ccell.2026.04.007
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Belgian American Educational Foundation
- Charles A. King Trust
- Wallonie-Bruxelles International
- Ludwig Center at Harvard
- Canadian Institutes of Health Research
- National Cancer Institute