Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Paediatric Patient
Abstract Novel clade 2.3.2.1e A(H5N1) virus was detected in cerebrospinal fluid but not in respiratory, rectal-swab and blood samples of an eight-year-old boy presenting with meningoencephalitis without respiratory symptoms. Cerebrospinal fluid A(H5N1)-hemagglutinin-specific antibody levels were higher than that of sera. Clinicians should be aware of emerging clade 2.3.2.1e A(H5N1) associated meningoencephalitis.
Authors
- Beng Lee Lim (ORCID: https://orcid.org/0000-0002-1033-9484)
- Priyanka Abraham (ORCID: https://orcid.org/0000-0002-5296-4499)
- Le Nguyen Truc Nhu (ORCID: https://orcid.org/0000-0002-7685-9730)
- Warangkana Chantima
- Le Van Tan (ORCID: https://orcid.org/0000-0002-1791-3901)
- Guy Edward Thwaites (ORCID: https://orcid.org/0000-0002-2858-2087)
- Nguyễn Thanh Hùng (ORCID: https://orcid.org/0000-0002-6944-2419)
- Chee Wah Tan (ORCID: https://orcid.org/0000-0001-9837-1413)
- Phaik Yeong Cheah (ORCID: https://orcid.org/0000-0001-6327-3266)
- Sebastian Maurer‐Stroh (ORCID: https://orcid.org/0000-0003-0813-9640)
- Trinh Son Tung (ORCID: https://orcid.org/0000-0003-2497-8073)
- Piyada Supasa (ORCID: https://orcid.org/0009-0006-3931-0569)
- Nguyễn Thu Hương (ORCID: https://orcid.org/0000-0002-7009-2815)
- Tran Nguyen Phuong Thao
- Paul Klenerman (ORCID: https://orcid.org/0000-0003-4307-9161)
- Lam Anh Nguyet
- Phung Nguyen The Nguyen (ORCID: https://orcid.org/0000-0003-2444-1786)
- Muneeswaran Selvaraj
- Tran Tan Thanh (ORCID: https://orcid.org/0000-0002-8096-7750)
- Lam Minh Yen (ORCID: https://orcid.org/0000-0002-5126-110X)
- Nguyen Thi Han Ny (ORCID: https://orcid.org/0000-0002-9833-2921)
- Vichapon Tiacharoen
- Tran Minh Nhut
- Nguyen To Anh (ORCID: https://orcid.org/0000-0001-8814-4436)
- David I. Stuart (ORCID: https://orcid.org/0000-0002-3426-4210)
- Le Thi Tam Uyen
- Kanpong Boonthaworn
- Ragil Dien
- Pham Tieu Kieu
- Adul Dulsuk
- Barbara Kronsteiner (ORCID: https://orcid.org/0000-0003-0867-2867)
- Nguyễn Văn Vĩnh Châu (ORCID: https://orcid.org/0000-0003-4668-1019)
- Wanwisa Dejnirattisai
- Tran Thi Thanh Tam (ORCID: https://orcid.org/0009-0003-4635-2482)
- Susanna Dunachie (ORCID: https://orcid.org/0000-0001-5665-6293)
- Prapassorn Poolchanuan (ORCID: https://orcid.org/0000-0003-1668-4147)
- Do Duong Kim Han
- Jurre Y. Siegers (ORCID: https://orcid.org/0000-0002-0246-7830)
- Wee Chee Yap (ORCID: https://orcid.org/0000-0001-8470-5806)
- Nghiêm My Ngoc
- Martha Zewdie (ORCID: https://orcid.org/0000-0003-2155-5550)
- Le Kim Thanh
- Truong Hoang Chau Truc
- Cao Minh Hiep
- Tran Thanh Thuc
- Eva Simarmata
- Aiete Dijokaite-Guraliuc
- Ngo Ngọc Quang Minh
- Dư Tuấn Quy
- Jennifer Hill
- Cao Thu Thuy (ORCID: https://orcid.org/0000-0003-3894-0949)
- Vo Tan Hoang (ORCID: https://orcid.org/0009-0001-9097-7565)
- Screaton Gavin
- Sandy Tze-Minn Mak
- Nguyen Thi Thu Hong (ORCID: https://orcid.org/0009-0004-4993-6616)
- Vu Thi Ty Hang
- Alessandro Sette
- Chang Liu
- Raph L Hamers
- Raksha Das
- Le Nguyen Thanh Nhan
- Alba Grifoni
- H Rogier van Doorn
- Tayipto Tayipto
- C Louise Thwaites
- Tassawan Poomchaichote
- Vu Duy Thanh
- Narisara Chantratita
- Nguyen Thi Thao
- Lin-Fa Wang
- for the SEACOVARIANTS and H5N1 Consortia
- Nick Day
- Anuraj Shankar
- Suwatrti Suwarti
- Juthathip Mongkolsapaya
- Sophon Iamsirithaworn
- Pham Ngoc Long
- Mary Chambers
- Erik A Karlsson (ORCID: https://orcid.org/0000-0001-6004-5671)
- Tran Van Dinh
- Nguyen Thanh Dung
- E Yvonne Jones
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- University of Oxford (GB)
- Children's Hospital 2 (VN)
- Institut Pasteur du Cambodge (KH)
- Oxford University Clinical Research Unit (VN)
- Hospital for Tropical Diseases (VN)
- Children's Hospital 1 (VN)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1093/ofid/ofag283
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00