Encounter of Organic Electrochemical Reactions and Liquid-Phase Peptide Synthesis: Development of Electrochemical Peptide Synthesis

Our group has been developing organic electrochemical reactions (since 1994) and liquid-phase peptide synthesis (since 2002) mostly independently of each other. The merger of electrochemistry and peptides had been a long-cherished goal of our group, yet apart from the limited example of electrochemical disulfide bond formation, the two had never encountered. Herein, we describe electrochemical peptide synthesis using triarylphophines as recyclable “coupling reagents,” where electrochemistry and peptides are merged.