Distinct supraspinal neural pathways underlie licking-induced alleviation of pain sensation and aversion in male mice
ZI) neuronal ensembles are efferent to the hindlimb region of the primary somatosensory cortex (S1HL) and the ventral tegmental area (VTA), which regulate the sensory and affective components of licking-induced analgesia, respectively. These findings unveil critical cross-modal supraspinal pathways that enable tactile input to differentially regulate the sensory and affective components of nociception.
Authors
- Yao Jia-xin
- Hao-Di Tang
- Yuncheng Luo
- Ruotian Jiang (ORCID: https://orcid.org/0000-0001-5322-6802)
- Xia Zhang
- Rong Luo
- Fan Lei
- Li-Mei Yi
- Hong-Bin Wang
- Fan Zhang (ORCID: https://orcid.org/0009-0007-6373-0755)
- Xin Li (ORCID: https://orcid.org/0000-0001-7733-439X)
- Tao Zhu
- Jiao Jiao
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.celrep.2026.117363
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan Province Science and Technology Support Program
- West China Hospital, Sichuan University