Overexpression of HIF-1α via small activating RNA enhances CAR-T cell function in hypoxic microenvironments
-CAR-T cells with an anti-CTLA4 nanobody resulted in synergistic tumour regression and improved infiltration in SCID-NOD mice, without significant toxicity. Collectively, activating endogenous HIF-1α in CAR-T cells is proposed as a promising strategy for the safe and effective treatment of solid tumors within hypoxic microenvironments.
Authors
- Iqra Ajmal (ORCID: https://orcid.org/0000-0002-5239-3972)
- Muhammad Asad Farooq (ORCID: https://orcid.org/0000-0002-8792-4171)
- Na Huang (ORCID: https://orcid.org/0000-0001-7961-0677)
- Songshan Zhu (ORCID: https://orcid.org/0000-0003-0000-2332)
- Wanjun He
- Xiqian Zhang (ORCID: https://orcid.org/0009-0001-5338-8884)
- Guangxian Xu
- Dan Jiang
- Kai Cui
- Qi Chen
Institutions
- Guangdong Medical College (CN)
Publication Details
- Journal
- Pharmacological Research
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.phrs.2026.108235
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00