ABSTRACT NUMBER: ESOC2026A2099 BRAIN CARE SCORE FOR FRENCH-SPEAKING PATIENTS: A PROSPECTIVE STUDY ON MOTIVATION TO IMPROVE BRAIN HEALTH

Abstract Background and aims Promoting brain health is essential for the prevention of stroke, dementia, and depression, which share a substantial burden of modifiable risk factors. The Brain Care Score (BCS) was developed to support risk reduction by assessing these factors and empowering patients to adopt prevention strategies. As no validated French-language tools currently address modifiable brain health determinants, we aimed to validate a French version of McCance Brain Care Score (BCS-F) and examine its association with patients’ motivation to improve brain health. Methods The BCS was translated into French by two independent translators and validated by an expert committee. 95 patients (mean age 70.7±13.4 years, 39% female, mean MoCA score 22.3±5.5/30) were recruited from the Cognitive Disorders Outpatient Clinic (03.2024-01.2025). 43 participants received the BCS-F and 52 received standard of care (SoC). Primary outcomes included willingness to improve brain health determinants and specific items targeted for change. Results Groups were comparable in demographics and general cognitive performance. Willingness to improve brain health was reported by 81 % (n=35) of the BCS-F group versus 48% (n=25) of the SoC group. Commonly targeted changes included blood pressure control, aerobic activity, and alcohol consumption. Use of the BCS-F was associated with a 69% higher likelihood of reporting willingness to improve brain health (risk ratio: 1.69, p<0.001), adjusting for age. The number needed to treat was 3. Conclusions The BCS fills a gap in accessible brain health assessment tools for French-speaking patients and may help inform and empower individuals to reduce their risk of stroke, dementia, and depression. Conflict of interest Hadrien M. Lalive: no disclosures; Arthur J.L. Watkins: no disclosures; Mathilde d’Esneval: no disclosures; Alexandra Rhally: no disclosures; Sophie Bernasconi-Xhepa: no disclosures; Alma Lingenberg: no disclosures; Jasper Senff: no disclosures; Sanjula D Singh: no disclosures; Marie-Gabrielle Duperron: no disclosures; Frédéric Assal: no disclosures; Jonathan Rosand: no disclosures; Lukas Sveikata: no disclosures.