ABSTRACT NUMBER: ESOC2026A2304 PREVALENCE, PATTERNS AND ASSOCIATIONS OF COGNITIVE DYSFUNCTION 6 MONTHS AFTER STROKE DUE TO INTRACEREBRAL HEMORRHAGE: A PROSPECTIVE COHORT STUDY

Abstract Background and aims Cognitive impairment is common after intracerebral hemorrhage (ICH), yet its prevalence, patterns, and associations are poorly understood; we therefore investigated these factors in a prospective cohort study at 6 months post-ICH. Methods We included 329 consecutive patients with stroke due to ICH who were admitted to University College London Hospital hyperacute stroke unit (which serves an ethnically-diverse population of 1.6 million people) between January 2017 and January 2020 from the Stroke Investigation Group in North and Central London (SIGNAL) registry. We concuted univariate analysis for prevelance and adjusted multivariate logistic regression analysis for predictors (significance defined P < 0.05). Cognitive impairment was defined as < 26 on the Montreal Cognitive Assessment (MoCA); we also assessed impairment in cognitive sub-domains. Results Cognitive impairment was common (74.16%), with largely mild deficits (median MoCA = 19, IQR 15-13). Language was most impacted (57.75%), followed by visuospatial/executive functions (46.81%), memory (43.77%), and attention (37.39%). Predictors included age (OR 3.03; 95% CI 1.55—6.13, P = 0.001), NIHSS (OR 2.34; 95% CI 1.26—4.31; P = 0.007), stroke recurrence (OR 5.31; 95% CI 1.29—21.79; P = 0.020), CAA (OR 4.11; 95% CI 1.41—11.95; P = 0.009), lobar ICH (OR 2.13; 95% CI 1.11—4.09; P = 0.022), volume (OR 2.81; 95% CI 1.21—6.53; P = 0.016) and SVD burden (OR 2.18; 95% CI 1.14—4.16; P = 0.019). Conclusions We describe the prevalence, patterns, and associations of cognitive impairment 6 months after ICH, which could help to understand mechanisms, identify patients at risk, and develop rational prevention strategies. Conflict of interest Authors have nothing to disclose.