ABSTRACT NUMBER: ESOC2026A1457 THE RELATIONSHIP BETWEEN LEVELS OF NEUROINFLAMMATORY BIOMARKERS AND NEUROPLASTICITY IN THE ACUTE PERIOD OF HEMORRHAGIC STROKES

Abstract Background and aims To evaluate the levels and relationship between the inflammatory marker vascular cell adhesion molecule-1 (VCAM-1) and the neuroplasticity marker glial cell line-derived neurotrophic factor (GDNF) in patients with acute hemorrhagic stroke. Methods Sixty-five patients with hemorrhagic stroke (30 women, 35 men; mean age 62.3 years) were examined. Hemorrhage types included subarachnoid (8.4%), parenchymal (53%), ventricular (9.6%), subarachnoid-ventricular (8.4%), and parenchymal-ventricular (6%). Stroke severity and functional status were assessed using the Glasgow Coma Scale, Barthel Index, and modified Rankin Scale. Serum VCAM-1 and GDNF levels were measured by enzyme-linked immunosorbent assay. Hemorrhage volume was determined using brain computed tomography. Results Elevated VCAM-1 expression was observed within the first 24 hours after stroke onset and showed a positive correlation with hemorrhage volume, with higher levels detected in patients with large intracerebral hemorrhages. GDNF levels demonstrated an inverse correlation with hemorrhage volume on day 12. Patients with an unfavorable clinical course had high VCAM-1 levels combined with reduced GDNF concentrations. In contrast, patients with a favorable course exhibited lower VCAM-1 levels and a significant increase in GDNF by day 12. During the early recovery period, VCAM-1 levels correlated with the Barthel Index, while GDNF levels correlated with the modified Rankin Scale. Conclusions Measurement of serum VCAM-1 and GDNF levels may be useful for assessing disease severity, predicting outcomes, and supporting personalized therapeutic strategies in patients with hemorrhagic stroke. Conflict of interest Fayzullo Mallayev: nothing to disclose