Electrophysiological profile after a First Unprovoked Seizure - a prospective high-density EEG study

Brain network alterations in non-lesional patients who later develop epilepsy can be detected with HD-EEG before a formal clinical diagnosis is established In first-seizure patients, changes in functional connectivity and spectral power are not primarily driven by CNS-active medication, but rather might reflect an underlying susceptibility to seizures EEG derived power and functional connectivity measures may therefore help identify patients at high risk of developing epilepsy and could support clinical decision-making regarding early treatment .