ABSTRACT NUMBER: ESOC2026YS137 REDUCTION OF MOTOR DEFICIT IN PATIENTS AFTER ISCHEMIC STROKE ON THE BACKGROUND OF AMANTADINE TREATMENT

Abstract Background and aims Stroke remains a global health problem. In Ukraine, during martial law, its incidence increased, affecting young people and increasing the level of disability. Methods 130 patients with ischemic stroke (mean age 52.5 ± 14.5 years) who were undergoing rehabilitation treatment were examined. Clinical and neurological examination, assessment of motor deficit with determination of muscle tone (Ashworth and Sidelkovsky scale), neuropsychological testing, and quality of life assessment (SF-36) were performed. Results Types of strokes among the examined: atherothrombotic (47.5%), embolic (15%), hemodynamic (12.5%), lacunar (23.75%), hemorheological microocclusion (1.25%). Motor deficit was detected in 75%, vestibular — in 82%, sensory — in 58%, neuropsychiatric disorders — in 47% of patients. Group 1 (n=58): spastic hypertension (according to the Ashworth scale). Group 2 (n=37): spastic-plastic tone (according to the Ashworth and Sidelkowski scale). Amantadine was administered intravenously for 6 days, then 100 mg orally (group 2) for 3 months. After 10 days, motor activity and muscle tone improved in both groups. After 3 months, group 2 demonstrated better and faster motor recovery, improved gait, cognitive abilities, and quality of life. Conclusion A detailed assessment of muscle tone allows for targeted treatment. Amantadine accelerates motor recovery, improves cognitive functions, and quality of life in post-stroke patients. Conflict of interest Nazarii Kalynovych “nothing to disclose”, Kateryna Tarianyk “nothing to disclose”, Liudmyla Derymedvid “nothing to disclose”