ABSTRACT NUMBER: ESOC2026YS212 ACUTE HYPERTENSIVE HEMORRHAGIC STROKE HAS A UNIQUE EXPRESSION PROFILE OF LONG NON-CODING RNA IN PLASMA EXOSOMES

Abstract Background and aims Acute hypertensive hemorrhagic stroke (HICH) is characterized by rapid onset, high disability and mortality rates. Currently, there is a lack of biomarkers that accurately reflect its pathological progression, and clinical interventions rely on empirical judgment. Exosomes carrying long non-coding RNAs (lncRNAs) have emerged as ideal non-invasive biomarkers due to their stable enrichment in plasma and ability to cross the blood-brain barrier. Methods Acute hypertensive hemorrhagic stroke (HICH) is characterized by rapid onset, high disability and mortality rates. Currently, there is a lack of biomarkers that accurately reflect its pathological progression, and clinical interventions rely on empirical judgment. Exosomes carrying long non-coding RNAs (lncRNAs) have emerged as ideal non-invasive biomarkers due to their stable enrichment in plasma and ability to cross the blood-brain barrier. Results A total of 352 differentially expressed lncRNAs were identified, including 76 upregulated and 276 downregulated. Bioinformatics analysis revealed that the target genes of these lncRNAs were primarily enriched in pathways such as the IL-17 signaling pathway, aldosterone synthesis and secretion, lysosomes, and glycolipid biosynthesis in the nerve sheath. qRT-PCR validation demonstrated that lncRNAs such as NONHSAG111409 exhibited significant specific expression. This study indicates that HICH patients exhibit a specific lncRNA expression profile in plasma exosomes during the acute phase, and the related lncRNAs are promising as novel biomarkers for disease diagnosis and prognosis assessment. Conflict of interest Li Jiangmin:nothing to disclose