A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer
T-cell-mediated cytotoxicity, uncovering a tumor-intrinsic mechanism of immune evasion and nominating the WICC-NOTUM axis as a selective and tractable therapeutic target to overcome immunotherapy resistance in CRC.
Authors
- Parham Minoo (ORCID: https://orcid.org/0000-0003-1057-0042)
- Constance A. M. Finney (ORCID: https://orcid.org/0000-0002-8459-8462)
- Aralia Leon‐Coria (ORCID: https://orcid.org/0000-0003-3000-1453)
- Oliver F. Bathe (ORCID: https://orcid.org/0000-0003-2305-4602)
- Arshad Ayyaz (ORCID: https://orcid.org/0009-0004-8573-2012)
- Elleine Allapitan
- Naomi Chege
- Arshdeep Kaur (ORCID: https://orcid.org/0000-0002-8956-4990)
- Julian Chua
- Areeba Maqsood
- Parnika Sakthivel
- Anneke Korver
- Mahdin Uddin
- Fynnis Mitchell
Institutions
- University of Calgary (CA)
- Alberta Children's Hospital (CA)
- Institute of Cancer Research (CA)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.xcrm.2026.102776
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arnie Charbonneau Cancer Institute, University of Calgary
- University of Calgary
- Cancer Research Society
- Natural Sciences and Engineering Research Council of Canada