ABSTRACT NUMBER: ESOC2026A2346 TEMPORAL MUSCLE THICKNESS TO SUPPORT REVASCULARIZATION DECISIONS IN ACUTE ISCHAEMIC STROKE

Abstract Background and aims Temporal muscle thickness (TMT), measured on routine non-contrast computed tomography (NCCT), is increasingly used as a reliable surrogate marker of global sarcopenia. When evaluating eligibility for reperfusion therapies in acute ischemic stroke (AIS), objective assessment of pre-stroke functional status may be challenging. TMT may provide an imaging-based biomarker to support estimation of pre-stroke disability, assessed using the modified Rankin Scale (mRS). This study aimed to evaluate the association between TMT and pre-stroke functional status in patients with AIS. Methods We included all adult consecutive patients treated for AIS at a tertiary centre during a period of 6 months. TMT was measured on admission NCCT by neuroradiologist blinded to clinical variables, according to a standardized protocol. Results A total of 404 patients were analysed (mean age 76.6 years). Patients with pre-stroke mRS 0–1 (group 1) and pre-stroke mRS 2 (group 2) demonstrated the highest mean TMT (6.6 [1.9] mm and 6.6 [2.1] mm, respectively). Mean TMT was lower in patients with pre-stroke mRS 3 (group 3; 5.5 [1.6] mm) and lowest in those with pre-stroke mRS 4–5 (group 4; 4.5 [1.4] mm). Overall, a significant difference in mean TMT was observed across pre-stroke mRS groups (one-way ANOVA, F = 13.62; df = 3,387; p < 0.001). Conclusions TMT is an easily obtainable value measured on NCCT. It may aid objective assessment of pre-stroke functional status helping guide revascularization therapy decision-making. Acknowledgements Horizon Europe project CHAngeing – Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function (Grant Agreement No. 101087071). Conflict of interest Katarina Rados: nothing to disclose, Andre Alves: nothing to disclose, Marcelo Queiroz: nothing to disclose, Joao Andre Sousa: nothing to disclose, Henrique Queirós: nothing to disclose, Fernando Silva: nothing to disclose, Gustavo Santo: nothing to disclose, Emanuel Martins: nothing to disclose, Branko Malojcic: nothing to disclose, Joao Sargento-Freitas: nothing to disclose Figure 1 - belongs to Results