Gene Expression Levels of Ferroptosis Suppressor Protein ( <i>FSP1</i> ) and Ferroptosis Inducer ( <i>ACSL4</i> ) and Their Correlation With Clinicopathological Features in Colorectal Cancer Patients

Background and Aim: in colorectal tumors. Methods: Thirty colorectal tumor tissues and thirty adjacent healthy tissues were subjected to gene expression study. Total RNA extraction from all tissues was completed and cDNA was synthesized from RNA. A qPCR was used for the gene expression analysis. Expression data were evaluated by SPSS software and the clinical importance of the genes was evaluated by ROC test. Results: using ROC test showed an area under the curve (AUC) of 0.78 (95% CI: 0.6143-0.9229), with a sensitivity of 80% and a specificity of 60% (95% CI: 0.4060-0.7734) and a cut-off of 1.3. Conclusion: has clinical potentials as a diagnostic biomarker in CRC.