ABSTRACT NUMBER: ESOC2026A2416 LONG-TERM FUNCTIONAL OUTCOME IN PATIENTS WITH ACUTE ISCHEMIC STROKE DUE TO ANTERIOR CIRCULATION LARGE VESSELS OCCLUSION TREATED WITH MECHANICAL THROMBECTOMY- DATA FROM EVERYDAY CLINICAL PRACTICE

Abstract Background and aims Acute ischemic stroke (AIS) due to anterior large vessel occlusion (aLVO) is associated with high mortality and long-term disability. The aim of our study was to investigate the long-term functional outcomes of patients with AIS due to aLVO treated with mechanical thrombectomy (MT), and to identify predictors of favourable long-term functional outcomes and mortality. Methods Our prospective study included 127 consecutive patients with AIS due to aLVO treated with MT. They were matched with a control group based on gender, age, pre-stroke morbidity, and initial NIHSS score. The follow-up period was one year. Functional outcome was assessed using the modified Rankin Scale (mRS). Results After one year of follow-up, a significantly higher proportion of patients treated with MT achieved good functional outcomes compared to those receiving medical management (47.2% vs. 22.0%, p=0.000), while lower proportion died in this group within one year (33.1% vs. 54.3%, p=0.000).The only independent predictor of a good one-year functional outcome was a favorable outcome at 90 days. Independent predictors of mortality included older age, higher NIHSS score, higher Charlson Comorbidity Index, and the presence of symptomatic intracranial hemorrhage (SICH). A good 90-day functional outcome was a negative predictor of one-year mortality. Conclusions Patients treated with MT have better functional outcomes and higher survival rates at one-year follow-up. A good functional outcome at 90 days independently predicts both favorable one-year outcomes and lower mortality. Other significant predictors of long-term mortality include older age, higher baseline NIHSS score, higher Charlson Comorbidity Index, and the presence of SICH. Conflict of interest The authors declare that they have no conflict of interests.