ABSTRACT NUMBER: ESOC2026A123 ATRIAL CARDIOPATHY IN EMBOLIC STROKES OF UNDETERMINED SOURCE (ESUS)

Abstract Background and aims Embolic Strokes of Undetermined Source (ESUS) accounts for about 9-25% of all ischemic strokes. Atrial cardiopathy (AC) is a recently described pathology of left atrium and found to be associated with embolic strokes. This study has aimed to study the prevalence and outcomes of atrial cardiopathy among patients with ESUS. Methods This is a prospective, observational study conducted in our centre. Atrial cardiopathy was diagnosed by the presence of any one of the defined biomarkers (electrocardiogram, echocardiogram or serum) at baseline. All the patients were followed up after 90 days. The study cohort was divided into two groups: ESUS with AC and ESUS without AC. Both the groups were compared using Mann Whitney U test. Fisher’s exact test was used to identify the parameter associated with recurrent stroke. p<0.05 was considered statistically significant. Results A total of 62 patients were included in the study with a mean age of 59.2(5.6) years. 48 patients (76%) were included in ESUS with AC group and 15 patients (24%) were included in ESUS without AC group. NT-proBNP was the most common AC biomarker found in 24 (39%) patients followed by elevated left atrial diameter found in 23 (37%) patients. Recurrent stroke was seen in 11 (18%) patients during 90-days followup. Abnormal P-wave terminal force V1 was significantly associated with stroke recurrence (p=0.054). Conclusions There is a high prevalence of AC among patients with ESUS and NT-proBNP >250 pg/mL is the most common biomarker. Abnormal PTFV1 may be associated with stroke recurrence. Conflict of interest Lakshmi Priya Lalitha : nothing to disclose; Prof Mahendra Javali : nothing to disclose; Dr Pradeep R : Nothing to disclose