ABSTRACT NUMBER: ESOC2026A1629 INTRAVENOUS THROMBOLYSIS IMPACT ON FUNCTIONAL OUTCOME OF PATIENTS WITH ACUTE ISCHEMIC STROKE AND MILD NEUROLOGICAL DISABILITY

Abstract Background and aims Results of recent studies showed that dual antiplatelet therapy (DAPT) is non-inferior to intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) and mild neurological disability. The aim of our study was to investigate an impact of IVT on functional outcome in patients with AIS and baseline NIH Stroke Scale/Score (NIHSS) ≤ 5 compared to DAPT. Methods We retrospectively included patients from the register of hospitalized AIS patients with baseline NIHSS ≤ 5 who were treated with IVT or DAPT. Patients were matched according to baseline clinical and demographic characteristics. Functional outcome was assessed by the modified Rankin score (mRS). Data was analyzed using standard statistical tests in SPSS Statistics 26.0 software. Results We included 127 patients (mean age 59.9±15.7 years, 58.2% of males), 72 patients treated with IVT and 55 with DAPT. Apart from diabetes mellitus (p=0.04) and cardiomyopathy (p<0.01) which were more prevalent in DAPT group, there were no other significant difference between groups. In our group of patients, IVT was associated with lower NIHSS after 24 hours (p=0.039) and at discharge (p=0.033), but without impact on mRS at discharge (p=0.473) and mRS after 90 days (p=0.484). Hemorrhagic transformation of infarct was more common in IVT group (p=0.05), but without influence on symptomatic intracranial hemorrhage (sICH) occurrence (p=0.505). Conclusions In our study, patients with AIS and mild neurological deficit who were treated with IVT demonstrated a tendency toward accelerated recovery; however, this treatment did not significantly affect overall functional outcome when compared to DAPT, while maintaining comparable safety profiles. Conflict of interest All authors have noting to disclose.