ABSTRACT NUMBER: ESOC2026A2329 CHANGE IN CEREBRAL HEMODYNAMIC PARAMETERS IN PATIENTS WITH OBESITY EXPERIENCING SIGNIFICANT WEIGHT LOSS. THE HEM-OB STUDY

Abstract Background and aims The relationship of obesity with small vessel disease remains controversial. The HemOb study aims to evaluate hemodynamic and functional parameters in patients with obesity undergoing bariatric surgery and achieving significant weight loss. Methods Twenty free-of-cardiovascular-disease-patients with indication for bariatric surgery accepted to participate and signed informed consent (after ethics committee approval). Each participant was assessed twice: just before surgery; and as soon as possible once they had lost at least 25% of their initial weight. We gather and compare clinical data (age, sex, cardiovascular risk factors and medications), anthropometric data (weight, height, BMI and waist circumference) and systemic and cerebral hemodynamic data (basal arterial pressure, ankle-brachial index, endothelium-dependent vasodilation in braquial artery, carotid IMT and atheromatous plaques; and speedometers of extracranial and proximal segments of intracranial arteries using ultrasonography). Results Two patients were finally excluded (one lost-to-follow-up, one unable to achieve target weight). The mean age was 44±8.3 years and 61% were women. The mean weight lost was 43 ±15Kg, and the mean IMC difference was 14.7±5. Compared to themselves preintervention (Pre), participants postintervention (Post) show lower systolic arterial pressure (Pre136±11.4 vs Post122.9±13.1 mmHg; p0.002); higher peak systolic velocity in intracranial ICA (Pre70.8±18.5 vs Post85.7±13.9 cm/sec; p0.03) and MCA (Pre83.9±25.6 vs Post97.7±18.1 cm/sec; p0.01). Anchial-brachial index and endothelium-dependent vasodilation show non-significant improvements. Conclusions Obese patients losing at least 25% of their original weight show significant changes in key intracranial hemodynamic parameters, linked to systolic blood pressure lowering. Conflict of interest M Teresa Montalvo Moraleda: nothing to disclose. Alvaro Bonelli Franco:nothing to disclose.Tamara Diaz Vico: nothing to disclose. Camilo Castellon Pavon:nothing to disclose. Irene Grao Torrente:nothing to disclose. Manuel Duran Poveda: nothing to disclose. Jose Fernandez-Ferro: nothing to disclose