ABSTRACT NUMBER: ESOC2026A1834 FUNCTIONAL OUTCOME AFTER ISCHAEMIC STROKE AND INTRACEREBRAL HAEMORRHAGE – AN ANALYSIS FROM THE SWISS STROKE REGISTRY

Abstract Background and aims Acute ischaemic stroke (AIS) is perceived to have better outcomes compared to intracerebral haemorrhage (ICH). We compared functional outcome 3 months after AIS and ICH in a nationwide stroke registry. Methods We analyzed prospectively collected data of all patients with AIS or ICH between 2014-2022 from the Swiss Stroke Registry. Primary outcome was 3-month modified Rankin Scale (mRS) score, analyzed using binary and ordered multivariate logistic regression. Sensitivity analysis excluded patients who received IV thrombolysis (IVT) or endovascular treatment (EVT). We tested the interaction between admission symptom severity (measured using NIHSS) and event type (AIS vs ICH). Results We included 41,812 patients with AIS (median [IQR] NIHSS 3 [1-8], 8,630 patients/20.2% received IVT and 6925 patients/16.6% received EVT) and 4,171 with ICH (median [IQR] NIHSS 8 [3-16]). Overall, 26,936 patients with AIS (64.4%) and 1,499 patients with ICH (35.9%) had a good functional outcome (mRS 0-2). 5,961 patients with AIS (10.52%) and 1,435 patients with ICH (28.04%) died within 3 months. ICH was independently associated with poor outcome (binary regression for mRS 0-2: adjusted odds ratio [aOR] 0.45, 95% confidence interval [CI] 0.41-0.50, p<0.001; ordered regression for mRS: common aOR 1.40, 95%CI 1.36-1.45, p<0.001). Sensitivity analysis showed consistent results (binary: aOR 0.54, 95%CI 0.49-0.61, p<0.001, ordered regression: aOR 0.57, 95%CI 0.44-0.70, p<0.001). There was a significant interaction between NIHSS and event type (p<0.001, figure). Conclusions Prognosis after ICH is worse compared to AIS, which is only partly explained by higher stroke severity in patients with ICH. Conflict of interest Janis Rauch: nothing to disclose Figure 1 - belongs to Results