ABSTRACT NUMBER: ESOC2026LB211 CLOT TYPE IS A DETERMINING FACTOR IN STROKE SEVERITY AND PROGNOSIS: EXPERIENCE OF A SINGLE-CENTER, LARGE-VOLUME STROKE CENTER.

Abstract Background and aims We aimed to determine the relationship between clot type and stroke severity and long-term outcomes at the clinical level. Methods For this purpose, clots obtained from patients who underwent endovascular treatment using the combined mechanical thrombectomy method and complete recanalization due to acute ischemic stroke in our hospital were analyzed in the laboratory. Results Results Baseline characteristics A total of 67 patients were included in the analysis, of whom 37 were assigned to Group E (eritrocyte rich clot) and 30 to Group F (fibrin rich clot). Baseline demographic and clinical characteristics were well balanced between the two groups. There were no significant differences in baseline stroke severity, with median NIHSS scores of 14 in Group E and 12 in Group F (p = 0.15), nor in baseline ASPECT scores (9 vs 10, p = 0.33). The prevalence of major vascular risk factors, including hypertension, diabetes mellitus, and atrial fibrillation, was comparable between groups. At 90 days, Group E demonstrated significantly better functional outcomes compared with Group F. The proportion of patients achieving good functional outcome (mRS 0–2) was 43% in Group E versus 13% in Group F (p = 0.018). Conversely, poor functional outcome (mRS >2) occurred in 57% of Group E patients and 87% of Group F patients. Conclusions Group E was independently associated with improved 90-day functional outcome, and this benefit was consistent across different levels of stroke severity. Baseline NIHSS remained the strongest predictor of outcome. Conflict of interest