The intimate relationship between restless legs syndrome and stroke

Restless legs syndrome shows a bidirectional relationship with stroke. On the one hand, restless leg syndrome may be a risk factor for stroke. On the other hand, stroke can trigger or exacerbate restless leg syndrome. Restless leg syndrome shares several pathophysiological mechanisms with stroke, and restless leg syndrome therapies may, emerging data suggest, reduce long-term cardiovascular risk. Mark Greener explains further.