Lifelong Exercise as a Modulator of <scp>CD4</scp> <sup>+</sup> T Cell Immunometabolism

BACKGROUND: T cell competence by favourably modulating their metabolic programming. METHODS: T cell metabolism, with particular emphasis on the developmental window of adolescence and the long-term benefits of early and sustained physical training across the lifespan. Molecular mechanisms linking exercise to metabolic reprogramming of T cells were summarised in parallel with attenuation of immunosenescence and inflammation over the lifespan. RESULTS: T cell metabolism, enhancing oxidative phosphorylation at rest and glycolytic control upon activation, thereby improving Th17/Treg balance, reducing chronic inflammation and enabling effective effector T cell responses. In this context, exercise initiated early in life may act as a critical modulator by promoting optimal immune function from childhood and establishing a functional peak that helps preserve immune competence during aging. CONCLUSIONS: T cell metabolism, strengthening immune balance and preserving immune function during aging.

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Publication Details

Journal
European Journal of Clinical Investigation
Published
2026-05-01
DOI
https://doi.org/10.1111/eci.70204
Primary Topic
Exercise and Physiological Responses
Type
article
Field-Weighted Citation Impact
0.00

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article

Lifelong Exercise as a Modulator of CD4 + T Cell Immunometabolism

Bruna Spolador de Alencar Silva, José Teixeira, Manuel João Coelho-e-Silva, Paulo J. Oliveira et al.
European Journal of Clinical Investigation
Exercise and Physiological Responses
article

Lifelong Exercise as a Modulator of CD4 + T Cell Immunometabolism

Bruna Spolador de Alencar Silva, José Teixeira, Manuel João Coelho-e-Silva, Paulo J. Oliveira, José Cesar Rosa‐Neto, Amanda Veiga Sardeli, Ricardo R. Agostinete, Helena Batatinha, Fábio Santos Lira, Alessandra Peres
article en

Abstract

BACKGROUND: T cell competence by favourably modulating their metabolic programming. METHODS: T cell metabolism, with particular emphasis on the developmental window of adolescence and the long-term benefits of early and sustained physical training across the lifespan. Molecular mechanisms linking exercise to metabolic reprogramming of T cells were summarised in parallel with attenuation of immunosenescence and inflammation over the lifespan. RESULTS: T cell metabolism, enhancing oxidative phosphorylation at rest and glycolytic control upon activation, thereby improving Th17/Treg balance, reducing chronic inflammation and enabling effective effector T cell responses. In this context, exercise initiated early in life may act as a critical modulator by promoting optimal immune function from childhood and establishing a functional peak that helps preserve immune competence during aging. CONCLUSIONS: T cell metabolism, strengthening immune balance and preserving immune function during aging.

European Journal of Clinical InvestigationVol. 56(5)
Universidade Federal de Ciências da Saúde de Porto Alegre (BR), University of North Carolina at Greensboro (US), Universidade de São Paulo (BR), ERA Arqueologia (PT), Hospital Regional de Presidente Prudente (BR), University of Coimbra (PT), University of Birmingham (GB), Universidade Estadual Paulista (Unesp) (BR)
European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Openalex Percentile: Top 12%
Exercise and Physiological Responses
DOIOpen Access PDFOpenAlex
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