Methylation Marks Breast Cancer Metastasis: The Roles of m6A-Modified miRNAs and lncRNAs

-methyladenosine), play a crucial role in how cancer develops, adapts, and resists therapy. This review covers recent advances in understanding how these modifications regulate two major groups of regulatory RNAs, microRNAs and long noncoding RNAs. Our review highlights that methylation can alter the production, stability, and activity of these RNAs specifically in the context of breast cancer, influencing cell growth, migration, invasion, and resistance to chemotherapy, all of which are key processes in metastasis. We discuss how changes in RNA methylation, regulated by enzymes that add, remove, or recognize these marks, help breast cancer cells adapt to their environment, evade immune detection, and colonize new tissues. The evidence strongly suggests that RNA methylation and its control of regulatory RNAs drives breast cancer progression and survival. Targeting these pathways may allow for more precise diagnostic tests, risk prediction, and development of new treatments. However, further research is required to unravel how these modifications interact with other cellular processes and to translate these findings into effective therapies.