<i>NTRK</i> Gene Fusions: A Compendium of Fusion Partners and Tumor Types
PURPOSE: gene fusions. METHODS: gene fusions were identified via literature searches (PubMed), a search of a clinical trials database (larotrectinib), and searches of two genomic databases (Memorial Sloan Kettering and Children's Hospital of Philadelphia). RESULTS: was found in the highest number of different tumor types. CONCLUSION: gene fusion partners across various tumor types and highlights the importance of selecting a pan-tumor fusion-partner agnostic test that can identify both known and novel fusion partners to identify patients who may benefit from treatment with TRK inhibitors.
Authors
- Vadim Bernard-Gauthier
- Erin R. Rudzinski (ORCID: https://orcid.org/0000-0002-7591-956X)
- Arthur M. Buchberg (ORCID: https://orcid.org/0000-0002-0543-5631)
- T. Laetsch
- Angshumoy Roy (ORCID: https://orcid.org/0000-0001-7248-8576)
- Karen Huang
- Julia Glade Bender (ORCID: https://orcid.org/0000-0001-5316-6440)
- David S. Hong
- Alexander Drilon
- Soo-Ryum Yang (ORCID: https://orcid.org/0000-0002-1051-502X)
- Marilyn M. Li (ORCID: https://orcid.org/0000-0002-4253-2369)
- Matteo Repetto
- Jinhua Wu (ORCID: https://orcid.org/0000-0002-8511-3949)
- Lauren Gutstein
- Nicoletta Brega (ORCID: https://orcid.org/0000-0002-5091-4631)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Children's Hospital of Philadelphia (US)
- The University of Texas MD Anderson Cancer Center (US)
- Bayer (United States) (US)
- Baylor College of Medicine (US)
- Cornell University (US)
- Bayer (Italy) (IT)
- Texas Children's Hospital (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1200/po-25-01150
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00