ABSTRACT NUMBER: ESOC2026A2160 THE INFLUENCE OF NEUROINFLAMMATION ON EARLY COGNITIVE IMPAIRMENT IN HEMORRHAGIC STROKE

Abstract Background and aims Hemorrhagic stroke (HS) is associated by a high risk of disability and persistent neurological sequelae. Neuroinflammation, in addition to primary focal damage, contributes to disease progression. Pro-inflammatory cytokines and matrix metalloproteinases disrupt the blood-brain barrier, develop perifocal edema and neuron dysfunction. However, the role of inflammation in early cognitive impairment after HS remains poorly understood. This study was to evaluate the relationship of neuroinflammatory markers with the severity of early cognitive impairment in patients with HS. Methods 68 patients with primary intracerebral hemorrhage (ICH) were examined. All patients were examined during the acute period of stroke. Cognitive functions were assessed using the MoCA scale, and stroke severity was assessed using the NIHSS scale. The volume of the hematoma was determined by computed tomography (CT). The levels of pro-inflammatory cytokines IL-1b, IL-6 and matrix metalloproteinase-9 (MMP-9) were measured in blood serum. The correlation method was used for the analysis. Results Early cognitive impairment was detected in 42 (61.8%) patients with ICH. A decrease in MoCA significantly correlated with an increase in IL-6 (r≈-0.43; p<0.05) and MMP-9 (r≈-0.46; p<0.05) levels. In patients with high levels of neuroinflammatory markers, cognitive deficits were more pronounced regardless of the volume of intracerebral hemorrhage and severity of stroke according to NIHSS. Conclusions Neuroinflammation is a significant factor in the formation of early cognitive impairment in HS. Evaluation of inflammatory markers can improve the accuracy of early diagnosis of cognitive deficits and substantiates the need for a personalized approach to rehabilitation. Conflict of interest Fatkhullaeva Nozimakhon: nothing to disclose