ABSTRACT NUMBER: ESOC2026YS289 PREDICTORS OF THE DEVELOPMENT OF HEMORRHAGIC TRANSFORMATION AND SYMPTOMATIC INTRACEREBRAL HEMORRHAGE IN PATIENTS WITH ANTERIOR CIRCULATION ACUTE ISCHEMIC STROKE TREATED WITH MECHANICAL THROMBECTOMY

Abstract Background and aims Hemorrhagic transformation (HT) is a relatively common complication in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) treated with mechanical thrombectomy (MT). If it is symptomatic intracerebral hemorrhage (SICH), it carries an increased risk of unfavourable functional outcome and lethality. Our work aimed to examine the early predictors of the occurrence of HT and SICH in patients treated with MT. Methods The study included 127 patients with AIS due to anterior circulation LVO who underwent MT. The development of HT and SICH was defined as a categorical variable (yes/no). SICH was diagnosed according to the SITS-MOST criteria, which include the presence of parenchymal hematoma and neurological deterioration for ≥4 NIHSS points. Results The development of HT was detected in 22.8% of patients treated with MT who had a higher initial value of the NIHSS score and a higher glycemic value on admission compared to the group that did not develop HT. SICH was detected in 7.1% of patients who differed from the group without SICH only in terms of higher initial NIHSS score values. Independent predictors of the occurrence of HT in patients treated with MT were higher values ​​of NIHSS score at the first examination (OR 1.09; 95% CI (1.01-1.17), p=0.019) and elevated glycemic values ​​on admission (OR 1.21; 95% CI (1.02-1.43), p=0.027). Higher values ​​of the NIHSS score at the first examination were the only independent predictor of occurrence of SICH in patients treated with MT (OR 1.13; 95% CI (1.02-1.26), p=0.025). Conflict of interest The authors declare that they have no conflict of interests.