ABSTRACT NUMBER: ESOC2026A951 IMPACT OF INFLAMMATORY BIOMARKERS ON FUNCTIONAL OUTCOME IN A COHORT OF PATIENTS WITH ACUTE LVO STROKE UNDERGOING MECHANICAL THROMBECTOMY

Abstract Background and aims Despite significant advances in the acute management of ischaemic stroke, accurately monitoring response to endovascular thrombectomy (EVT) and predicting functional outcomes in patients with large vessel occlusion (LVO) remain challenging. In this context, acute-phase inflammatory blood biomarkers may provide valuable prognostic information and enhance current prediction models. This study aimed to identify variables associated with unfavorable functional outcomes in patients with LVO stroke treated with EVT, defined as a modified Rankin Scale (mRS) score of 3–6 at 3 months, with a focus on acute-phase inflammatory biomarkers. Methods The clinical and laboratory data of 172 consecutive patients with LVO acute stroke (median age 77 years, Female 60%) treated with EVT were retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to identify variables independently associated with poor clinical outcomes (mRS 3-6 at 3 months). Results Median NIHSS score at admission was 16 and successful post-EVT recanalization (TICI 2b–3) was achieved in 73.8% of patients. Multivariate analysis demonstrated that older age (OR = 1.006, p = 0.038), higher NIHSS score at admission (OR = 1.027, p < 0.001), elevated C-reactive protein (CRP) levels at admission (OR = 1.003, p = 0.020), and increased neutrophil-to-lymphocyte ratio (NLR) at admission (OR = 1.015, p = 0.004) were independently associated with an unfavorable functional outcome (mRS 3–6). Conclusions In a consecutive cohort of patients with LVO ischaemic stroke treated with EVT, admission levels of the inflammatory biomarkers’ NLR and CRP were independently associated with functional outcome at 3 months. Conflict of interest Edoardo Ricci: Nothing to disclose. Giovanni Furlanis: Nothing to disclose. Milos Ajčević: Nothing to disclose. Katerina Iscra: Nothing to disclose. Michele Malesani: Nothing to disclose. Emanuele Vincis: Nothing to disclose. Gabriele Prandin: Nothing to disclose. Paola Caruso: Nothing to disclose. Marcello Naccarato: Nothing to disclose. Paolo Manganotti: Nothing to disclose. Table 1 - belongs to Results Table 2 - belongs to Conclusions Table 3 - belongs to Conclusions