ABSTRACT NUMBER: ESOC2026A158 LONG-TERM MORTALITY AFTER STROKE AMONG DIFFERENT AGE AND SEX GROUPS: A PROSPECTIVE COHORT STUDY FROM SHANGHAI

Abstract Background and aims Elucidating long-term mortality and risk determinants is critical for optimizing stroke care paradigms. In this study, we aimed to explore long-term mortality and associated risk factors of stroke patients over a median 16-year surveillance period in Shanghai, China. Methods A total of 1605 stroke patients enrolled in our registry from 2002 to 2007 were followed up until December 31, 2023 or the date of death. Standardized mortality ratios (SMRs) were calculated for the entire cohort and stratified by gender/age, with concurrent evaluation of risk factors associated with long-term mortality. Results Five hundred and forty-one (43.9%) stroke patients died during follow-up and the SMR was 4.47 (95% confidential interval [CI] 4.08–4.85). In the age group of < 60 years, the SMR was 2.15 (95% CI 1.63–2.67) for men, 0.94 (0.43–1.45) for women, respectively. In the patients aged ≥ 60 years, the SMR was 6.32 (95% CI 5.57–7.07) for men and 5.79 (4.93-6.65) for women. The older age at onset, history of hyperlipidemia and prior TIA/IS was independently associated with the long-term death. The Kaplan Meier plot depicted that those <60 years of age had better prognosis compared with the patients aged ≥60 years in both males and females. Conclusions The long-term mortality following acute stroke was higher compared with the general populations. The increasing age at onset, dyslipidemia and prior stroke history were associated with the long-term death. Aggressive public health interventions aimed at improving the control of risk factors and mitigating socioeconomic disparities are urgently needed. Conflict of interest all authors have nonting to disclose