ABSTRACT NUMBER: ESOC2026A1623 TRANSIENT GLOBAL AMNESIA (TGA) AND HIPPOCAMPAL DWI LESIONS: IS IT AGE-DEPENDENT?

Abstract Background and aims Rates of positive diffusion-weighted imaging (DWI) with hippocampal changes varies greatly in patients with transient global amnesia (TGA), with studies ranging from 0 to 80%. These variable rates are attributed to multiple factors, including timing of the scan after symptom onset, thickness of slices and b-value. We wanted to investigate if DWI changes on MRI were also age-dependent. TGA is most common in middle-aged to elderly patients (typically 50-80 years old, with a mean of 61-67 years). Methods All patients presenting to TIA clinic with a diagnosis of TGA, and who underwent MRI scans within the last 2 years were selected. The mean ages of DWI-positive and DWI-negative patients were calculated, and statistical analysis was completed to determine whether there was a significant difference between the ages. Results Out of 7250 patients presenting to TIA clinic within the last 2 years, 145 had a diagnosis of TGA. Out of these, 16 patients (11%) had positive DWI changes in the hippocampus. 12 of them had unilateral changes, and 4 showed bilateral changes. The mean age of DWI-negative patients was 69 (range from 48-100); the mean age of DWI-positive patients was 65 (range from 52-80). The calculated p-value was 0.08. Conclusions DWI changes on MRI in TGA patients are independent of the age of the patient. We are currently investigating whether DWI changes are linked to the duration of amnesia. Conflict of interest Fahad Musarrat: nothing to disclose, Safia Mohammed: nothing to disclose, Mohammed Moqsith: nothing to disclose