ABSTRACT NUMBER: ESOC2026OT101 MIGRAINE AND ISCHEMIC STROKE IN YOUNG ADULTS: A STUDY IN PROGRESS

Abstract Background and aims Migraine has been increasingly recognized as a potential risk factor for ischemic stroke, particularly in young adults. The underlying mechanisms linking migraine to cerebrovascular events remain incompletely understood and may involve inflammatory pathways, endothelial dysfunction, and genetic susceptibility. Data from North African populations are scarce, despite the high prevalence of migraine in young individuals. Methods This ongoing study aims to investigate the association between migraine and ischemic stroke in young adults and to explore clinical, vascular, and biological factors that may contribute to stroke risk in this population. Results We are conducting an observational study including young adults aged 18–50 years admitted for ischemic stroke at a tertiary university hospital. Clinical data collection includes migraine history (with or without aura), vascular risk factors, stroke characteristics, and etiological classification. In parallel, biological analyses focusing on inflammatory and vascular markers are planned. Comparative analyses will be performed between migraineurs and non-migraineurs to explore potential differences in stroke mechanisms and risk profiles. Conclusions We expect to identify distinct clinical and vascular profiles among young stroke patients with migraine compared to those without migraine. This study may improve understanding of migraine-related stroke risk and contribute to the development of targeted preventive strategies in young adults. Conflict of interest