ABSTRACT NUMBER: ESOC2026A777 RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ACTIVITY IN PATIENTS WITH ATRIAL FIBRILLATIONS AND ATRIAL FLUTTER

Abstract Background and aims Atrial fibrillation (AF) and atrial flutter (AFL) are the main course of cardioembolic stroke. The main cause of AF and AFl is arterial hypertension (AH) and inflammatory theory of arrhythmogenesis is rather new and interesting. Comparison of echocardiographic data in patients with paroxysmal and persistent atrial fibrillation and flutter in hypertensive people with different systemic inflammation and renin-angiotensin-aldosterone system activity isthe aim of this study. Methods 103 patients (pts) with hypertension and paroxysmal or persistent AF and persistent AFl were examined and divided to different groups according to highly specific C-reactive protein (CRP) and angiotensin converting enzyme (ACE) level in peripheral blood. Data of 44 people without arrhythmic anamnesis (23 pts with AH and 21 healthy persons) was used for control groups. Results Assessing the activity of ACE in the vast majority of pts with arrhythmias its increased level was observed in 82% versus 27% among patients in the comparison groups. These were 85 patients out of 103 and 12 patients out of 44 (p <0.05). 83% (86 pts with AF and AFl) had a significantly increased CRP rate versus 9% (4 pts without arrhythmias). It was noted that in patients with increased CRP level left ventricle mass index (LVMI) and E/A peak where significantly higher (p≤0.05) as in case of high ACE level. Conclusions Patients with AH who have passed AF and AFl episodes and have increased CRP and ACE levels have more severe left ventricle hypertrophy and diastolic dysfunction comparing to people with AH and without arrhythmias or healthy people. Conflict of interest Olena Marchenko. Nothing to disclose