ABSTRACT NUMBER: ESOC2026OT83 THE PROGNOSTIC VALUE OF NEUROINFLAMMATORY INDICES IN ACUTE ISCHEMIC STROKE

Abstract Background and aims Stroke was the leading cause of disabilities and cognitive deficits. Moreover, ischemic stroke accounted for 5.2% of all deaths worldwide in 2015 .The basic pathological cause of ischemic stroke is intravascular thrombosis, which can result in cerebral tissue necrosis and focal neuronal deficits. There are three known leading causes of ischemic strokes: 50% are caused by arteriosclerotic plaques of the cerebral vessels and the rupture of the arteriosclerotic plaque, 20% are caused by cardiogenic cerebral infarction, and 25% are caused by lacunar infarcts from small vessel lesions . In Uzbekistan, over 60,000 new stroke cases are reported each year. On average, more than 160 individuals experience a stroke every day, including about 25–30 cases daily in Tashkent alone Methods Identifying clinical, laboratory, and neuroimaging patterns of disease mechanisms and prognostic evaluation. Results The study included 40 patients hospitalized in the Intensive Neurology Department of the Tashkent state medical university Clinic. All patients diagnosed with acute ischemic stroke. Clinical evaluation included the NIHSS, modified Rankin Scale (mRS), and Barthel Index. Blood samples were analyzed to determine NLR, PLR, LMR, and SIRI ratios. Conclusions Patients with NIHSS >12 and mRS ≥3–4 demonstrated substantially higher levels of these indices compared to normal ranges. These findings indicate that post-stroke brain injury is invariably associated with activation of inflammatory responses, involving monocytes, macrophages, and neutrophils. Such activation contributes to secondary brain injury by expanding the ischemic zone, disrupting the blood-brain barrier, impairing microcirculation, and exacerbating cerebral edema. Conflict of interest