ABSTRACT NUMBER: ESOC2026A1975 PLATFORM STUDY FOR INTRACEREBRAL HAEMORRHAGE (PLINTH): RESULTS OF A FEASIBILITY STUDY

Abstract Background and aims Recruiting people with intracerebral haemorrhage (ICH) to clinical trials remains challenging. We did a feasibility study for a platform study for ICH (PLINTH). Methods Adults with incident ICH (or the legal representative of adults with incapacity) in NHS Lothian and Lanarkshire, Scotland, were shown (i) a <3-minute narrated video about this feasibility study before verbal consent, then (ii) personalised information about their ICH and uncertainties about their care before written consent. Researchers conducted semi-structured interviews at days 3 and 14 after written consent to obtain participants’ views about the two-stage consent process and taking part in a future PLINTH. The primary outcome is the proportion of people with incident ICH for whom there was at least one management uncertainty, consent to participate in this feasibility study, and willingness to consider participating in a future PLINTH. Results We screened 320 adults with ICH between 1 Oct 2023 to 30 Jun 2025. Of these, 200 (63%) were eligible, 197 (62%) were approached, 169 (53%) gave verbal consent, 165 (52%) gave written consent, and 140 (44%) met the primary outcome. Among 169 participants who gave verbal consent, 109 (64%) were from Lothian, median age was 73 years (IQR 59-83), 83 (49%) were female, 109 (64%) were diagnosed outside of usual office hours, and 164/168 (98%) with complete data had two or more relevant uncertainties about their care suitable for investigation in a future PLINTH. Conclusions The results of this feasibility study will culminate in a proposal for the most efficient design of a future PLINTH. Conflict of interest Tom Moullaali: nothing to disclose