ABSTRACT NUMBER: ESOC2026OT175 BLOOD PRESSURE VARIABILITY DURING EARLY MOBILITY TRAINING AFTER ACUTE STROKE: FINDINGS FROM THE AVERT DOSE TRIAL

Abstract Background and aims Blood pressure (BP) responses to early mobility training in acute ischaemic stroke are poorly characterised, despite their relevance for clinical safety and rehabilitation decision-making. Methods This study examines BP responses to positional changes during early mobility training and explores the influence of clinical and stroke-related characteristics. Results This is a secondary analysis of physiological data from the AVERT DOSE adaptive randomised controlled trial of early mobility training in mild to moderate acute ischaemic stroke. Participants received upright, task-specific mobility training initiated within 48 hours of stroke onset. Physiological measures, including systolic and diastolic BP, heart rate, and oxygen saturation were collected at standardised body positions before, during, and after the first mobility training session of the day across the first three days of early mobility following recruitment. Conclusions Primary outcomes were within-session and between-session changes in systolic BP across predefined body positions. Secondary outcomes included variability in physiological responses and their associations with clinical characteristics, such as age, stroke severity, pre-stroke fitness level, and tPA administration. Conflict of interest