Successful Reirradiation of Multiple Recurrent Lymphocytic Hypophysitis: A Case Report

Abstract Lymphocytic hypophysitis is a rare autoimmune inflammatory condition of the pituitary gland. For patients with disease refractory to corticosteroids and systemic agents, surgery is often pursued. However, given the anatomy of the suprasellar area, complete resection is difficult, and postoperative recurrence is common. Radiation therapy (RT) represents an alternative to surgery in those not suitable for resection or a means for further treatment in the setting of postsurgical recurrence. Given the rarity of the disease, data on the use of RT and its outcomes are sparse. Even more rare are examples regarding reirradiation for this uncommonly encountered condition. To add to the data in this space, we present the case of a patient with multiple recurrent lymphocytic hypophysitis who underwent 2 courses of RT as part of his treatment.